Herramientas de Accesibilidad
The present study reports the trypanocidal and cardioprotective properties of fractions derived from Lippia alba (Verbenaceae family) essential oils (EOs), in a murine model of chronic Chagas disease (ChD). This infection represents one of the most serious public health problems in Latin American countries, without an effective therapy for chronic infection and its eventual cardiac complications. In the model established herein, the therapeutic scheme which involved 30 oral and daily doses of OxiLim (a mix composed by fractions enriched in citral, caryophyllene oxide, and limonene) was not toxic and exhibited trypanocidal activity comparable to benznidazole (assessed by parasitic DNA quantification - qPCR); but with an additional protective effects against cardiomyopathy progression. This last finding was confirmed by both echocardiography (reduction in the maximum diameter of the cardiac silhouette), and heart histopathology (tissue recovery, abundant fibroblasts, and mild separation of cardiac fibers). Conversely, rats treated only with benznidazole showed a significant increase in cardiac diameter with severe fiber dilation, angiogenesis, and high diversity of immune infiltrate. This research reports a highly trypanocidal (similar to benznidazole) therapeutic scheme based on L. alba essential oil fractions (OxiLim), which also exhibits a positive cardioprotective effect in the course of chronic chagasic cardiomyopathy, in rats.
Industrial Crops and Products
Universidad de Santander UDES. Vigilada Mineducación.
Resolución otorgada por el Ministerio de Educación Nacional: No. 6216 del 22 de diciembre de 2005 / Personería Jurídica 810 de 12/03/96.
Institución sujeta a inspección y vigilancia por el Ministerio de Educación Nacional. Resolución 12220 de 2016.
Notificaciones administrativas y judiciales:
Copyright © 2021 - Todos los derechos reservados